Development of Fuzzy Applications for High Performance Induction Motor Drive

This chapter develops a sliding mode and fuzzy logic-based speed controller, which is named adaptive fuzzy sliding-mode controller (AFSMC) for an indirect field-oriented control (IFOC) of an induction motor (IM) drive. Essentially, the boundary layer approach is the most popular method to reduce the chattering phenomena, which leads to trade-off between control performances, and chattering elimination for uncertain nonlinear systems. For the proposed AFSMC, a fuzzy system is assigned as the reaching control part of the fuzzy sliding-mode controller so that it improves the control performances and eliminates the chattering completely despite large and small uncertainties in the system. A nonlinear adaptive law is also implemented to adjust the control gain with uncertainties of the system. The adaptive law is developed in the sense of Lyapunov stability theorem to minimize the control effort. The applied adaptive fuzzy controller acts like a saturation function in the thin boundary layer near the sliding surface to guarantee the stability of the system. The proposed AFSMC-based IM drive is implemented in real-time using digital signal processor (DSP) board TI TMS320F28335. The experimental and simulation results show the effectiveness of the proposed AFSMC-based IM drive at different operating conditions such as load disturbance, parameter variations, etc

Genomic–transcriptomic evolution in lung cancer and metastasis

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study. Analyses of 947 tumour regions, representing both primary and metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate the transcriptome as a major source of phenotypic variation. Gene expression levels and ITH relate to patterns of positive and negative selection during tumour evolution. We observe frequent copy number-independent allele-specific expression that is linked to epigenomic dysfunction. Allele-specific expression can also result in genomic–transcriptomic parallel evolution, which converges on cancer gene disruption. We extract signatures of RNA single-base substitutions and link their aetiology to the activity of the RNA-editing enzymes ADAR and APOBEC3A, thereby revealing otherwise undetected ongoing APOBEC activity in tumours. Characterizing the transcriptomes of primary–metastatic tumour pairs, we combine multiple machine-learning approaches that leverage genomic and transcriptomic variables to link metastasis-seeding potential to the evolutionary context of mutations and increased proliferation within primary tumour regions. These results highlight the interplay between the genome and transcriptome in influencing ITH, lung cancer evolution and metastasis

Recent Developments on Power Inverters

This book develops some methods and structures to improve the power inverters for different applications in a single-phase or three-phase output in recent years. The reduction of the switching devices and multilevel inverters as changing structure for the power inverters and PDM and PWM methods as changing control methods for the power inverter are studied in this book. Moreover, power inverters are developed to supply open-ended loads. Furthermore, the basic and advanced aspects of the electric drives that are control based are taught for induction motor (IM) based on power inverters suitable for both undergraduate and postgraduate levels. The main objective of this book is to provide the necessary background to improve and implement the high-performance inverters. Once the material in this book has been mastered, the reader will be able to apply these improvements in the power inverters to his or her problems for high-performance power inverters

Sensored Field Oriented Control of a Robust Induction Motor Drive Using a Novel Boundary Layer Fuzzy Controller

Physical sensors have a key role in implementation of real-time vector control for an induction motor (IM) drive. This paper presents a novel boundary layer fuzzy controller (NBLFC) based on the boundary layer approach for speed control of an indirect field-oriented control (IFOC) of an induction motor (IM) drive using physical sensors. The boundary layer approach leads to a trade-off between control performances and chattering elimination. For the NBLFC, a fuzzy system is used to adjust the boundary layer thickness to improve the tracking performance and eliminate the chattering problem under small uncertainties. Also, to eliminate the chattering under the possibility of large uncertainties, the integral filter is proposed inside the variable boundary layer. In addition, the stability of the system is analyzed through the Lyapunov stability theorem. The proposed NBLFC based IM drive is implemented in real-time using digital signal processor (DSP) board TI TMS320F28335. The experimental and simulation results show the effectiveness of the proposed NBLFC based IM drive at different operating conditions

An integrated fuzzy-image processing approach based infrared thermography for failure detection and classification of the steam traps

Temperature is one of the most common indicators for the structural health of equipment and components. Nowadays, infrared thermography (IRT) is widely used as a condition-monitoring tool using measurement of the temperature in real time in a non-invasive and non-contact manner to reducing system down time, catastrophic breakdown, and maintenance cost. In this paper, IRT is used for inspection of Steam traps in steam transporting processes using image processing technique and classification of failure intensity in an intelligent model. In the intelligent model, an infrared camera is initially used to capture the thermal image, which is imported as input. The failure detection is performed in two stages.

Pharmacodynamic and pharmacokinetic properties of the combined preparation of levothyroxine plus sustained- release liothyronine; a randomized controlled clinical trial

Abstract Background Understanding pharmacokinetics (PK) and pharmacodynamics (PD) of the sustained-release liothyronine (SR-T3) is of paramount importance to design therapeutic regimens that are able to simulate normal thyroid hormone secretion while avoiding excursions in the T3 serum concentration. Here, we designed a parallel randomized clinical trial to characterize the PK and PD of the combined preparations of LT4 + SR-T3 in hypothyroid patients. Methods Radioiodine-treated hypothyroid patients over 20 years of age, who attained euthyroidism with LT4 monotherapy were recruited from the Endocrine Clinic in Tehran. The patients were allocated to two intervention groups of group A: 9 µg SR-T3 plus 68.5 μg LT4 (ratio 1:7.5) and group B: 12 µg SR-T3 plus 60 µg LT4 (ratio 1:5), and a control group with LT4 monotherapy. For PD study, thyroid hormone profile was evaluated at 8 and 12 weeks intervals after intervention. To assess PK properties of SR-T3, T3-Cmax, T3-Tmax and AUC0 − 24 were calculated at the last visit. Results Serum T4 and FT4 concentrations decreased in the intervention groups after 3 months. No significant difference was observed in serum T3 and FT3 concentrations before and after intervention. Serum T3/T4 ratio increased significantly in the intervention groups after intervention, with the highest increase in group B from 8.6 ± 2.03 at baseline to 12.2 ± 1.6. Comparison of trial groups at follow-up showed no differences in serum TSH, T4, T3 and T3/T4 concentrations among different groups. During 24 h, minimal variation in serum T3 concentration was observed in group B with mean ∆T3 of 15.4 ± 10.5 ng/dl. T3-Tmax, T3-Cmax and AUC0 − 24 in the combined sustained-release preparation were 4.38 ± 1.1 h., 101.0 ± 5.7 ng/dl and 2257 ± 110 ng.h/L, respectively which were significantly different from the control group. Conclusion Combined treatment with a single dose of SR-T3 plus LT4 is associated with increased serum T3/T4 ratio and minimal excursions in serum T3 concentration during 24 h; however, it was not significantly different from the control group. To incorporate sustained-release T3 in the management of hypothyroidism, a higher ratio of SR-T3 to LT4 than that of the previously recommended by the international organizations is suggested. IRCT registration number IRCT20100922004794N13. https://www.irct.ir/search/result?query=IRCT20100922004794N13 . Registration date: 08/12/2021